_ _ _ _ _ _ Artur ¯ ¯ _ _ _ _ _ _Góra¯ ¯ ¯

Head of the Tunneling Group

Artur Gora received Ph.D. degree in Chemistry in 2002 from the Jagiellonian University in Poland. In 2004 he was awarded a JSPS fellowship, and from 2004 to 2006 he was working at the National Institute of Advanced Industrial Science and Technology in Japan. From 2010 to 2013, he has been Marie Curie fellow at the Loschmidt Laboratories of the Masaryk University in Brno, Czech Republic. Since 2014 he is a leader of Tunneling Group located in Biotechnology Centre, Silesian University of Technology. His main works are focused on protein engineering, inhibitors and drug design and software development facilitating molecular dynamic simulations results analysis and interpretation. Between 2016 and 2019 he was the Deputy Director for Science at Biotechnology Centre, Silesian University of Technology in Poland.

Important publications

Katarzyna Szleper, Mateusz Cebula, Oksana Kovalenko, Artur Góra, Agata Raczyńska, PUR-GEN: A Web Server for Automated Generation of Polyurethane Fragment Libraries. Computational and Structural Biotechnology Journal, 2024 doi: 10.1016/j.csbj.2024.12.004 ARTICLE^{Open Access}

Aravind Selvaram Thirunavukarasu, Katarzyna Szleper, Gamze Tanriver, Igor Marchlewski, Karolina Mitusinska, Artur Gora, Jan Brezovsky, Water Migration through Enzyme Tunnels Is Sensitive to the Choice of Explicit Water Model. Journal of Chemical Information and Modeling, 2024, doi: 10.1021/acs.jcim.4c01177 ARTICLE^{Open Access}

Weronika Bagrowska, Angelika Karasewicz, Artur Góra, Comprehensive analysis of acetylcholinesterase inhibitor and reactivator complexes: implications for drug design and antidote development. Drug Discovery Today 2024, 29(12), 104217, doi: 10.1016/j.drudis.2024.104217 ARTICLE

Agata Raczyńska, Artur Góra, Isabelle André. An overview on polyurethane degrading enzymes. Biotechnology Advances, 2024, 77, 108439, doi: 10.1016/j.biotechadv.2024.108439 ARTICLE

Carlos Acevedo-Rocha, Lukasz Berlicki, Uwe T. Bornscheuer, Dominic J. Campopiano, Pimchai Chaiyen, Janko Civic, Zhiqi Cong, Friedrich Johannes Ehinger, Sabine Flitsch, Artur Góra, Marko Hanzevacki, Jeremy N. Harvey, Donald Hilvert, Florian Hollfelder, Amanda Jarvis, Bruce R. Lichtenstein, Stefan Lutz, Thomas Malcomson, E. Neil G. Marsh, Neil R. McFarlane, Alexander McKenzie, Adrian Mulholland, Silvia Osuna, Joelle N. Pelletier, Agata Raczyńska, Gerard Roelfes, Lubom´ır Rul´ıˇsek, Peter Stockinger, Nicholas Turner, Francesca Valetti, Marc Van der Kamp, Mikael Widersten and Cathleen Zeymer. Enzyme evolution, engineering and design: mechanism and dynamics: general discussion. Faraday Discussion, 2024, doi: 10.1039/d4fd90022g

Carlos Acevedo-Rocha, Amulyasai Bakshi, Uwe T. Bornscheuer, Dominic J. Campopiano, Janko Civic, Ivana Drienovska, Friedrich Johannes Ehinger, Andrew Gomm, Artur Góra, Anthony P. Green, Marko Hanzevacki, Jeremy N. Harvey, Donald Hilvert, Meilan Huang, Amanda Jarvis, Shina Caroline Lynn Kamerlin, Bruce R. Lichtenstein, Louis Y. P. Luk, Stefan Lutz, E. Neil G. Marsh, Alexander McKenzie, Vicent Moliner, Adrian Mulholland, Silvia Osuna, Joelle N. Pelletier, Agata Raczyńska, Aditya Gopalakrishna Rao, Guto Rhys, Gerard Roelfes, Lubomir Rulisek, Peter Stockinger, Katarzyna Szleper, Sean Adeoti Thompson, Nicholas Turner, Marc Van der Kamp, Guangcai Xu and Cathleen Zeymer. Artificial, biomimetic and hybrid enzymes: general discussion. Faraday Discussion, 2024, doi: 10.1039/d4fd90024c.

Abdulrahman Alogaidi, Fraser Armstrong, Amulyasai Bakshi, Uwe T. Bornscheuer, Gareth Brown, Isabelle Bruton, Dominic J. Campopiano, Daniel Dourado, Friedrich Johannes Ehinger, Sabine Flitsch, Artur Góra, Anthony P. Green, Donald Hilvert, Sumire Honda, Meilan Huang, Rhiannon Jones, Thomas King, Bruce R. Lichtenstein, Michal Lihan, Louis Y. P. Luk, Tara C. Lurshay, Stefan Lutz, E. Neil G. Marsh, Alexander McKenzie, Ben Orton, Joelle N. Pelletier, Agata Raczyńska, Lubomir Rulisek, Peter Stockinger, Per-Olof Syren, Nicholas Turner, Francesca Valetti, Marc Van der Kamp and Lu Shin Wong. Biocatalysis for industry, medicine and the circular economy: general discussion. Faraday Discussion, 2024, doi: 10.1039/d4fd90025a.

Dorrazehi G.M.; Winkle M.; Desmet M.; Stroobant V.; Tanriver G.; Degand H.; Evrard D.; Desguin B.; Morsomme P.; Biboy J.; Gray J.; Mitusińska K.; Góra A.; Vollmer W.; Soumillion P.; PBP-A, a cyanobacterial DD-peptidase with high specificity for amidated muropeptides, exhibits pH-dependent promiscuous activity harmful to Escherichia coli. Scientific Reports. 2024, 14, 13999 doi: 10.1038/s41598-024-64806-x. ARTICLE^{Open Access}

Skalski T.; Zając E.; Jędrszczyk E.; Papaj K.; Kohyt J.; Góra A.; Kasprzycka A.; Shytum D.; Skowera B.; Ziernicka-Wojtaszek A.. Effects of γ-polyglutamic acid on grassland sandy soil properties and plant functional traits exposed to drought stress. Scientific Reports 2024, 14, 3769 doi: 10.1038/s41598-024-54459-1. ARTICLE^{Open Access}

Bzówka M.; Bagrowska W.; Góra A.; Recent Advances in Studying Toll-like Receptors with the Use of Computational Methods. J. Chem. Inf. Model., 2023, 63, 12, 3669–3687 doi: 10.1021/acs.jcim.3c00419  ARTICLE^{Open Access}

Raczyńska A.; Kapica P.; Papaj K.; Stańczak A.; Shyntum D.; Spychalska P.; Byczek-Wyrostek A.; Góra A.; Transient binding sites at the surface of haloalkane dehalogenase LinB as locations for fine-tuning enzymatic activity. PLoS ONE 2023 18(2), e0280776. doi: 10.1371/journal.pone.0280776 ARTICLE^{Open Access}

Bzówka M.; Mitusińska K.; Raczyńska A.; Skalski T.; Samol A.; Bagrowska W.; Magdziarz T.; Góra A.; Evolution of tunnels in α/β-hydrolase fold proteins—What can we learn from studying epoxide hydrolases? PLOS Computational Biology 2022, 18 (5), e1010119 doi: 10.1371/journal.pcbi.1010119  ARTICLE^{Open Access}

Mitusińska K.; Bzówka M.; Magdziarz T.; Góra A.; Geometry-Based versus Small-Molecule Tracking Method for Tunnel Identification: Benefits and Pitfalls. J. Chem. Inf. Model. 2022, 62, 24, 6803–6811. doi: 10.1021/acs.jcim.2c00985 ARTICLE^{Open Access}

Mitusińska K.; Góra A.; Bogdańska A.; Rożdżyńska-Świątkowska A.; Tylki-Szymańska ; Jezela-Stanek A.; Structural analysis of the effect of Asn107Ser mutation on Alg13 activity and Alg13-Alg14 complex formation and expanding the phenotypic variability of ALG13-CDG. Biomolecules 2022, 12(3), 398 doi: 10.3390/biom12030398 ARTICLE^{Open Access}

Papaj K.; Spychalska P.; Kapica P.; Fisher A.; Nowak J.; Bzówka M.; Sellner M.; Lill M.A.; Smieško ; Góra A.; Evaluation of Xa inhibitors as potential inhibitors of the SARS-CoV-2 Mpro protease. PloS ONE 2022, 17 (1), e0262482 doi: 10.1371/journal.pone.0262482 ARTICLE^{Open Access}

Mitusińka K.; Wojsa P.; Bzówka M.; Raczyńska A.; Bagrowska W.; Samol A.; Kapica P.; Góra A.; Structure-function relationship between soluble epoxide hydrolases structure and their tunnel network. Computational and Structural Biotechnology Journal 2022, 20, 193-205 doi: 10.1016/j.csbj.2021.10.042 ARTICLE^{Open Access}

Papaj K.; Spychalska P.; Hopko K.; Kapica P.; Fisher A.; Lill M.A.; Bagrowska W.; Nowak J.; Szleper K.; Smieško M.; Kasprzycka A.; Góra A.; Investigation of Thiocarbamates as Potential Inhibitors of the SARS-CoV-2 Mpro. Pharmaceuticals 2021, 14(11), 1153 doi: 10.3390/ph14111153 ARTICLE^{Open Access}

Bzówka M.; Mitusińska K.; Hopko K.; Góra A.; Computational insights into the known inhibitors of human soluble epoxide hydrolase. Drug Discovery Today 2021, 26(8):1914-1921 doi: 1016/j.drudis.2021.05. ARTICLE^{Open Access}

Mitusińska K.; Raczyńska A.; Wojsa P.; Bzówka M.; Góra A.; AQUA-DUCT: Analysis of Molecular Dynamics Simulations of Macromolecules with the use of Molecular Probes [Article v1. 0]. Living Journal of Computational Molecular Science 2021, 2 (1), 21383 doi: 10.33011/livecoms.2.1.21383 ARTICLE^{Open Access}

Fischer A.; Sellner M.; Mitusińska K.; Bzówka M.; Lill M. A.; Góra A.; Smieško M.; Computational Selectivity Assessment of Protease Inhibitors against SARS-CoV-2 Int. J. Mol. Sci. 2021, 22(4), 2065 doi: 10.3390/ ijms22042065 ARTICLE^{Open Access}

Jezela-Stanek A.; Blaz W.; Góra A.; Bochenska M.; Kusmierska K.; Sykut-Cegielska J.;, Proteins Structure Models in the Evaluation of Novel Variant (C.472_477del) in the MOSC2 Gene. Diagnostics 2020, 10, 821 doi:10.3390/diagnostics10100821 ARTICLE^{Open Access}

Bzówka M., Mitusińska K., Raczyńska A., Samol A., Tuszyński J.A., Góra A. Structural and Evolutionary Analysis Indicate that the SARS-CoV-2 Mpro is a Challenging Target for Small-Molecule Inhibitors Design , Int. J. Mol. Sci. 2020, 21(7), 3099 doi: 10.3390/ijms21093099. ARTICLE^{Open Access}

Mitusińska, K.; Skalski, T.; Góra, A. Simple Selection Procedure to Distinguish between Static and Flexible Loops. Int J Mol Sci 2020, 21, 2293, doi:10.3390/ijms21072293 ARTICLE^{Open Access}

Papaj, K.; Kasprzycka, A.; Góra, A.; Grajoszek, A.; Rzepecka, G.; Stojko, J.; Barski, J.-J.; Szeja, W.; Rusin, A. Structure–bioavailability relationship study of genistein derivatives with antiproliferative activity on human cancer cell. J Pharm Biomed Anal 2020, 185, 113216, doi:10.1016/J.JPBA.2020.113216. ARTICLE^{Open Access}

Mitusińska, K.; Raczyńska, A.; Bzówka, M.; Bagrowska, W.; Góra, A. Applications of water molecules for analysis of macromolecule properties. Comput Struct Biotechnol J 2020, 18, 355–365, doi:10.1016/j.csbj.2020.02.001. ARTICLE^{Open Access}

Magdziarz, T.; Mitusińska, K.; Bzówka, M.; Raczyńska, A.; Stańczak, A.; Banas, M.; Bagrowska, W.; Góra, A. AQUA-DUCT 1.0: structural and functional analysis of macromolecules from an intramolecular voids perspective. Bioinformatics 2019, doi:10.1093/bioinformatics/btz946, ARTICLE^{Open Access}

Subramanian, K.; Mitusińska, K.; Raedts, J.; Almourfi, F.; Joosten, H.-J.; Hendriks, S.; Sedelnikova, S. E.; Kengen, S. W. M.; Hagen, W. R.; Góra, A.; Martins dos Santos, V. A. P.; Baker, P. J.; van der Oost, J.; Schaap, P. J. Distant Non-Obvious Mutations Influence the Activity of a Hyperthermophilic Pyrococcus furiosus Phosphoglucose Isomerase. Biomolecules 2019, 9, 212, doi:10.3390/biom9060212. ARTICLE^{Open Access}

Mitusińska, K.; Magdziarz, T.; Bzówka, M.; Stańczak, A.; Gora, A.; Mitusińska, K.; Magdziarz, T.; Bzówka, M.; Stańczak, A.; Gora, A. Exploring Solanum tuberosum Epoxide Hydrolase Internal Architecture by Water Molecules Tracking. Biomolecules 2018, 8, 143, doi:10.3390/biom8040143. ARTICLE^{Open Access}

Baaden, M.; Barboiu, M.; Bill, R. M.; Casanova, S.; Chen, C.-L.; Conner, M.; Freger, V.; Gong, B.; Góra, A.; Hinds, B.; Horner, A.; Hummer, G.; Kumar, M.; Lokesh, M.; Mitra, S.; Noy, A.; Pohl, P.; Sadet, A.; Sansom, M.; Törnroth-Horsefield, S.; Vashisth, H. Structure and function of natural proteins for water transport: general discussion. Faraday Discuss 2018, 209, 83–95, doi:10.1039/C8FD90019A. ARTICLE

Baaden, M.; Borthakur, M. P.; Casanova, S.; Coalson, R.; Freger, V.; Gonzalez, M.; Góra, A.; Hinds, B.; Hirunpinyopas, W.; Hummer, G.; Kumar, M.; Lynch, C.; Murail, S.; Noy, A.; Sansom, M.; Song, Q.; Vashisth, H.; Vögele, M. The modelling and enhancement of water hydrodynamics: general discussion. Faraday Discuss 2018, 209, 273–285, doi:10.1039/C8FD90021C. ARTICLE

Płuciennik, A.; Stolarczyk, M.; Bzówka, M.; Raczyńska, A.; Magdziarz, T.; Góra, A. BALCONY: an R package for MSA and functional compartments of protein variability analysis. BMC Bioinformatics 2018, 19, 300, doi:10.1186/s12859-018-2294-z. ARTICLE^{Open Access}

Subramanian, K.; Góra, A.; Spruijt, R.; Mitusińska, K.; Suarez-Diez, M.; Martins dos Santos, V.; Schaap, P. J. Modulating D-amino acid oxidase (DAAO) substrate specificity through facilitated solvent access. PLoS One 2018, 13, e0198990. ARTICLE^{Open Access}

Magdziarz, T.; Mitusińska, K.; Gołdowska, S.; Płuciennik, A.; Stolarczyk, M.; Lugowska, M.; Góra, A. AQUA-DUCT: A ligands tracking tool. Bioinformatics 2017, 33, 2045–2046, doi:10.1093/bioinformatics/btx125. ARTICLE

Brezovsky, J.; Babkova, P.; Degtjarik, O.; Fortova, A.; Gora, A.; Iermak, I.; Rezacova, P.; Dvorak, P.; Kuta Smatanova, I.; Prokop, Z.; Chaloupkova, R.; Damborsky, J.  Engineering a de Novo Transport Tunnel. ACS Catal 2016, 6, 7597–7610, doi:10.1021/acscatal.6b02081. ARTICLE

Kozlikova, B.; Sebestova, E.; Sustr, V.; Brezovsky, J.; Strnad, O.; Daniel, L.; Bednar, D.; Pavelka, A.; Manak, M.; Bezdeka, M.; Benes, P.; Kotry, M.; Gora, A.; Damborsky, J.; Sochor, J. CAVER Analyst 1.0: Graphic tool for interactive visualization and analysis of tunnels and channels in protein structures. Bioinformatics 2014, 30, 2684–2685, doi:10.1093/bioinformatics/btu364. ARTICLE.

Gora, A.; Brezovsky, J.; Damborsky, J. Gates of enzymes. Chem Rev 2013, 113, 5871–5923, doi:10.1021/cr300384w. ARTICLE^{Open Access}

Hasan, K.; Gora, A.; Brezovsky, J.; Chaloupkova, R.; Moskalikova, H.; Fortova, A.; Nagata, Y.; Damborsky, J.; Prokop, Z. The effect of a unique halide-stabilizing residue on the catalytic properties of haloalkane dehalogenase DatA from Agrobacterium tumefaciens C58. In FEBS Journal; 2013; Vol. 280, pp. 3149–3159.

Brezovsky, J.; Chovancova, E.; Gora, A.; Pavelka, A.; Biedermannova, L.; Damborsky, J. Software tools for identification, visualization and analysis of protein tunnels and channels. Biotechnol Adv 2013, 31, 38–49. ARTICLE

Chovancova, E.; Pavelka, A.; Benes, P.; Strnad, O.; Brezovsky, J.; Kozlikova, B.; Gora, A.; Sustr, V.; Klvana, M.; Medek, P.; Biedermannova, L.; Sochor, J.; Damborsky, J. CAVER 3.0: A Tool for the Analysis of Transport Pathways in Dynamic Protein Structures. PLoS Comput Biol 2012, 8, doi:10.1371/journal.pcbi.1002708. ARTICLE^{Open Access}

Biedermannová, L.; Prokop, Z.; Gora, A.; Chovancová, E.; Kovács, M.; Damborský, J.; Wade, R. C. A Single Mutation in a Tunnel to the Active Site Changes the Mechanism and Kinetics of Product Release in Haloalkane Dehalogenase LinB. J Biol Chem 2012, 287, 29062–29074, doi:10.1074/jbc.M112.377853.

Software

More informations

Contact

Artur.Gora(at)polsl.pl

or

a.gora(at)tunnelinggroup.pl